Vol. 12 No. 3 (2026): Revista Ibero-Americana de Humanidades, Ciências e Educação — REASE

Qualis A3

DOI: https://doi.org/10.51891/rease.v12i3

Published: 2026-03-01

Artigos

IMPACT OF EARLY INTERVENTIONS ON THE PROGNOSIS OF SCHIZOPHRENIA: A SYSTEMATIC REVIEW Introduction: Schizophrenia, a serious mental illness associated with functional and social impairments, has its prognosis significantly influenced by the timing of therapeutic intervention. Recent studies have highlighted that early approaches, implemented during the first psychotic episode (FEP), are correlated with lower relapse rates, reduction of negative symptoms, and improved social reintegration. Specialized programs, such as Early Psychosis Programs, combine pharmacotherapy, psychotherapy, and family support, but gaps remain in the understanding of their impact over extended timescales, especially in populations with limited access to health services. Objective: To analyze, through a systematic review, the impact of early interventions on the prognosis of patients with schizophrenia, considering clinical, functional, and social outcomes in long-term studies. Methodology: The review followed the PRISMA checklist, using the PubMed, SciELO, and Web of Science databases, with articles published in the last 10 years. The descriptors were: "early intervention in psychosis", "schizophrenia prognosis", "long-term outcomes", "first episode psychosis", and "psychosocial interventions". Longitudinal studies (follow-up ≥5 years), randomized clinical trials, and prospective cohorts that evaluated early interventions were included. Case studies, narrative reviews, and articles without quantitative outcome assessments were excluded. Methodological quality was assessed using tools such as the Newcastle-Ottawa scale. Results: Of the 1,237 studies identified, 15 met the criteria. Early intervention programs were associated with a 40% reduction in hospitalizations and a 30% improvement in cognitive function after 10 years. Multidisciplinary models, such as cognitive-behavioral therapy combined with antipsychotics, have demonstrated greater effectiveness in preventing relapses compared to usual treatment. Studies in middle-income countries have highlighted structural barriers, such as lack of access to second-generation medications, limiting the sustainability of interventions. Conclusion: Early interventions have proven crucial for improving long-term outcomes in schizophrenia, with robust evidence on reduced disability and hospital costs. However, effective implementation requires cultural adaptations and investments in public health, especially in resource-limited regions. The integration of biopsychosocial approaches emerges as a priority strategy to optimize the prognosis of this population. Early intervention in psychosis. Schizophrenia prognosis. Long-term outcomes. First episode psychosis and psychosocial interventions.

José Jorge de Miranda Neto, Maria Luísa Miranda Macedo, Ana Luiza Freitas Teixeira, Giovanna Lucilla Ramos Griebeler

1-12
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DOI: https://doi.org/10.51891/rease.v12i3.23659
EFFICACY AND SAFETY OF MICROPROCESSOR-CONTROLLED PROSTHESES IN TRANSFEMORAL AMPUTEES: A SYSTEMATIC REVIEW OF CONTROLLED STUDIES

Hugo Lorran Souza Costa, Bárbara Morando Kalil Patrício, Bruno Ribeiro de Lima, Breno Alves de Souza Vaz

1-15
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DOI: https://doi.org/10.51891/rease.v12i3.24712
PREDICTIVE TECHNOLOGIES IN BRAZILIAN POLICE INTELLIGENCE: STRATEGIC POTENTIAL, INSTITUTIONAL CONSTRAINTS AND CONSTITUTIONAL LIMITS

Eduardo de Oliveira Melo, Allan Rodrigues de Freitas, Leovanio Castro Almeida, Giêr Monteiro Memória, Flávio Carvalho Cavalcante

1-13
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DOI: https://doi.org/10.51891/rease.v12i3.24715
ANXIETY AND SMOKING: IMPACTS ON SELF-PERCEPTION OF HEALTH AND ATTEMPTS TO QUIT SMOKING

Dulce Maria Caixeta Oliveira, Geovanna Alves Pacheco, Natália Luana de Souza, Maria Cristina de Moura Ferreira, Carla Denari Giuliani, Marcelle Aparecida de Barros Junqueira

1-26
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DOI: https://doi.org/10.51891/rease.v12i3.24506
FROM REACTIVE POLICING TO PROSPECTIVE INTELLIGENCE: THE IMPLEMENTATION OF THE "SISTEMA PAREDÃO" AND THE MODERNIZATION OF PUBLIC SECURITY IN AMAZONAS

Adna de Melo Rossi, Ernandes Costa Meirelis, Lucas Alexandre Silva da Silva, Marcelle Queiroz Pinheiro, Flávio Carvalho Cavalcante

1-16
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DOI: https://doi.org/10.51891/rease.v12i3.24680
EMOTIONAL REGULATION IN COLLEGE STUDENTS: A LITERATURE REVIEW

Denise de Matos Manoel Souza, Heloisa Bruna Grubits

1-15
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DOI: https://doi.org/10.51891/rease.v12i3.24494
AGREEMENT ON NON-PROSECUTION IN BRAZILIAN MILITARY CRIMINAL LAW: NORMATIVE LIMITS AND COMPARATIVE ANALYSIS BETWEEN STATE AND FEDERAL MILITARY JUSTICE SYSTEMS

Bruno Gouveia Pietrobon

1-19
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DOI: https://doi.org/10.51891/rease.v12i3.24498
IMPACTS OF REMOTE NURSING EDUCATION ON UNDERGRADUATE STUDENTS DURING THE COVID-19 PANDEMIC

Larissa Alexandre Leite, Elis Maria Jesus Santos, Misley Alencar Silva, Vinícius Alves de Figueredo, Guilherme Neves Bastos, Tamires de Alcantara Medeiros, Maysa de Oliveira Barbosa, Regina Petrola Bastos Rocha

1-19
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DOI: https://doi.org/10.51891/rease.v12i3.24200
MATHEMATICAL LITERACY IN THE LITERACY PHASE: AN ANALYSIS OF THE DISSONANT TEACHING PRACTICES OF TEACHERS IN THE CLASSROOM

Márcio Urel Rodrigues, Maria Edjane Santos Sapucaia

1-23
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DOI: https://doi.org/10.51891/rease.v12i3.24533
STRATEGIC INTELLIGENCE IN THE MILITARY POLICE OF AMAZONAS: THEORETICAL FOUNDATIONS, KNOWLEDGE MANAGEMENT AND PERSPECTIVES IN THE AMAZONIAN CONTEXT

Eurico Dias Teixeira Neto, Keila Regina Delgado Vieira Barboza, Reinaldo José da Silva Coelho, Victor Maciel Gomes Lima, Victor Freire de Oliveira, Flavio Carvalho Cavalcante

1-14
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DOI: https://doi.org/10.51891/rease.v12i3.24738
POST-TRAUMATIC STRESS DISORDER: DIAGNOSTIC UPDATES, NEUROBIOLOGICAL MECHANISMS, AND EVIDENCE-BASED INTERVENTIONS

José Jorge de Miranda Neto, Maria Luísa Miranda Macedo

1-14
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DOI: https://doi.org/10.51891/rease.v12i3.23846
PSYCHIATRIC DISORDERS AS DYSFUNCTIONS OF SLEEP–IMMUNE–BRAIN NETWORK DYNAMICS: A SYSTEMS-LEVEL NEUROCOGNITIVE FRAMEWORKABSTRACT

José Jorge de Miranda Neto, Maria Luísa Miranda Macedo, Ana Luiza Freitas Teixeira, Giovanna Lucilla Ramos Griebeler

1-27
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DOI: https://doi.org/10.51891/rease.v12i3.23996
THE USE OF ARTIFICIAL SWEETENERS AND THEIR ENDOCRINOMETABOLIC EFFECTS IN TYPE 2 DIABETES MELLITUS

Eduarda Eleutério Sartore, Lívia Busatto Pena, Júlia da Silva Souza Freire, Carlos Eduardo Dilen da Silva, Raphael Cardoso Rodrigues, Walace Fraga Rizo

1-15
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DOI: https://doi.org/10.51891/rease.v12i3.24263
EMERGING AND RE-EMMERGING DOENÇAS IN THE BRAZILIAN CONTEXT

Maria Rita Esthefane Lisboa Frutuoso, Bruna Lívia Timbó de Araújo Balthazar, Kelly Denise Machado Motter, Samuel Mafra Garcia, Jackson Balthazar de Arruda Camara, Kallyne Lima de Carvalho

1-19
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DOI: https://doi.org/10.51891/rease.v12i3.24568
IMPACTS OF SELLA TURCICA ANATOMICAL VARIATIONS ON THE DIAGNOSIS OF PITUITARY NEOPLASMS

Guilherme de Melo Lima Medeiros, Franklin Gustavo Rodrigues Vitor, Antônio Cabral da Silva Neto, Rodrigo Eduardo Lopes Costa, Sálvio Adonias Oliveira Nóbrega de Mello, Francisco Orlando Rafael de Freitas

1-17
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DOI: https://doi.org/10.51891/rease.v12i3.24180
TRAFFIC AND SAFETY ON HIGHWAY AM-070:LIMITS OF INFRASTRUCTURE AND HUMAN BEHAVIOR

Hermeson Nery Belota, Denison Melo de Aguiar, Flávio Humberto Pascarelli Lopes, Bruno Patrício de Azevedo Campos

1-18
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DOI: https://doi.org/10.51891/rease.v12i3.24403

Artigo de Revisão

FROM THE REDUCTION OF INFANT MORTALITY TO THE COMPLEXIFICATION OF CARE: RECONFIGURATIONS OF CHILD HEALTH CARE IN BRAZIL

Carlos Walmyr de Mattos Oliveira, Suelen Goecks Oliveira, Yudelsi Galan Ramirez, Laenne Ágata Valentim, Luiz Farias Cantalixto de Melo, Eloysa Vicente Silva, João Artur Veloso Antunes

1-21
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DOI: https://doi.org/10.51891/rease.v12i3.24481

Vol. 12 No. 3 (2026): Revista Ibero-Americana de Humanidades, Ciências e Educação — REASE

Artigos

EFFICACY AND SAFETY OF MICROPROCESSOR-CONTROLLED PROSTHESES IN TRANSFEMORAL AMPUTEES: A SYSTEMATIC REVIEW OF CONTROLLED STUDIES

PREDICTIVE TECHNOLOGIES IN BRAZILIAN POLICE INTELLIGENCE: STRATEGIC POTENTIAL, INSTITUTIONAL CONSTRAINTS AND CONSTITUTIONAL LIMITS

ANXIETY AND SMOKING: IMPACTS ON SELF-PERCEPTION OF HEALTH AND ATTEMPTS TO QUIT SMOKING

FROM REACTIVE POLICING TO PROSPECTIVE INTELLIGENCE: THE IMPLEMENTATION OF THE "SISTEMA PAREDÃO" AND THE MODERNIZATION OF PUBLIC SECURITY IN AMAZONAS

EMOTIONAL REGULATION IN COLLEGE STUDENTS: A LITERATURE REVIEW

AGREEMENT ON NON-PROSECUTION IN BRAZILIAN MILITARY CRIMINAL LAW: NORMATIVE LIMITS AND COMPARATIVE ANALYSIS BETWEEN STATE AND FEDERAL MILITARY JUSTICE SYSTEMS

IMPACTS OF REMOTE NURSING EDUCATION ON UNDERGRADUATE STUDENTS DURING THE COVID-19 PANDEMIC

MATHEMATICAL LITERACY IN THE LITERACY PHASE: AN ANALYSIS OF THE DISSONANT TEACHING PRACTICES OF TEACHERS IN THE CLASSROOM

STRATEGIC INTELLIGENCE IN THE MILITARY POLICE OF AMAZONAS: THEORETICAL FOUNDATIONS, KNOWLEDGE MANAGEMENT AND PERSPECTIVES IN THE AMAZONIAN CONTEXT

POST-TRAUMATIC STRESS DISORDER: DIAGNOSTIC UPDATES, NEUROBIOLOGICAL MECHANISMS, AND EVIDENCE-BASED INTERVENTIONS

PSYCHIATRIC DISORDERS AS DYSFUNCTIONS OF SLEEP–IMMUNE–BRAIN NETWORK DYNAMICS: A SYSTEMS-LEVEL NEUROCOGNITIVE FRAMEWORKABSTRACT

THE USE OF ARTIFICIAL SWEETENERS AND THEIR ENDOCRINOMETABOLIC EFFECTS IN TYPE 2 DIABETES MELLITUS

EMERGING AND RE-EMMERGING DOENÇAS IN THE BRAZILIAN CONTEXT

IMPACTS OF SELLA TURCICA ANATOMICAL VARIATIONS ON THE DIAGNOSIS OF PITUITARY NEOPLASMS

TRAFFIC AND SAFETY ON HIGHWAY AM-070:LIMITS OF INFRASTRUCTURE AND HUMAN BEHAVIOR

Artigo de Revisão

FROM THE REDUCTION OF INFANT MORTALITY TO THE COMPLEXIFICATION OF CARE: RECONFIGURATIONS OF CHILD HEALTH CARE IN BRAZIL

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