EVALUATION OF THE ANTICARCOGENIC POTENTIAL OF VINEGAR, USING THE EPITHELIAL TUMOR TEST (ETT) IN SOMATIC CELLS OF DROSOPHILA METHOGASTER

Abstract

Cancer is one of the leading causes of global mortality, facing challenges such as drug resistance. Apple cider vinegar, known for its antioxidant and anti-inflammatory properties, was evaluated for its anticarcinogenic effects in Drosophila melanogaster. Epithelial tumor assays analyzed different concentrations, both alone and in combination with Doxorubicin (DXR). Vinegar at 0.25%, 0.5%, and 1% did not exhibit carcinogenic effects. When combined with DXR, it significantly reduced tumor frequency, suggesting a synergistic effect. The results indicate that apple cider vinegar does not induce carcinogenesis and may enhance chemotherapeutic efficacy. Thus, it emerges as a promising adjuvant in cancer treatment, reinforcing the importance of exploring phytotherapeutics in oncology. Future studies should further investigate the underlying mechanisms and its clinical applications.