PHARMACEUTICAL SUPPLY CHAIN MONITORING: A CASE STUDY IN A PUBLIC LABORATORY INTEGRATED WITH A SYSTEMATIC LITERATURE REVIEW

Abstract

Monitoring the pharmaceutical supply chain is a critical component for ensuring the quality, safety, and traceability of medicines, particularly in the context of increasingly complex global supply networks. This study aimed to analyze the monitoring process of suppliers of active pharmaceutical ingredients (APIs) and excipients in a Public Pharmaceutical Laboratory, integrating empirical evidence from a case study with a systematic literature review conducted according to PRISMA guidelines. The search identified 312 studies, of which 12 were included in the final analysis. In the case study, 142 supply chains were mapped, with response rates above 85%. The results revealed gaps in traceability, inconsistencies in data standardization, and limited visibility of logistical intermediaries, corroborating findings reported in the literature. Conversely, high supplier engagement and methodological advances, such as the use of flowcharts for supply chain analysis, were observed, representing a relevant practical contribution. The comparison highlighted structural convergences, including the importance of risk-based management, as well as gaps, particularly in the adoption of digital technologies. It is concluded that structured supply chain monitoring, combined with data standardization and integration into the quality system, is essential to strengthen governance and regulatory compliance in the pharmaceutical sector.