PHYSICAL PERFORMANCE AND PERCEIVED EXERTION AFTER MULTICOMPONENT SUPPLEMENTATION WITH PHOSPHATIDYLSERINE AND AMINO ACIDS IN HIFT PRACTITIONERS: AN EXPLORATORY FIXED-SEQUENCE STUDY

Abstract

This article compared physical performance and rating of perceived exertion after ten days of a multicomponent formulation containing phosphatidylserine and amino acids in men engaged in high-intensity functional training. Eight participants started the study; one did not complete the final assessment, and seven had complete data across all three assessments. The study was exploratory, within-subject, placebo-controlled, and fixed-sequence, with baseline, post-supplementation, and post-placebo assessments separated by a washout period. The formulation provided 600 mg/day phosphatidylserine, 150 mg/day L-histidine, 75 mg/day L-cysteine, 300 mg/day L-proline, and 7.2 µg/day methylcobalamin. Maximum strength, local muscular endurance, 12-minute running performance, and perceived exertion were assessed. No convergent pattern of benefit was observed across outcomes. Ring-row performance showed a higher number of repetitions post-supplementation than at baseline, with no difference versus placebo. In the Cooper test, the post-supplementation versus post-placebo contrast favored the active condition, although the overall effect was not statistically significant. These findings are exploratory and do not support generalized ergogenic efficacy.