PHARMACEUTICAL ATTENTION TO COMBAT THE INDISCRIMINATE USE OF DIPYRONE: A REVIEW

Abstract

Dipyrone is an analgesic, anti-inflammatory, and antipyretic medication from the class of over-the-counter drugs (OTCs), and it began selling in Brazil under the brand name Novalgin®. Its commercialization began to be known worldwide until the 1970s when cases of agranulocytosis, a clinical condition of urgent immunological deficit, began to be reported. This drug is highly sought after due to its easy accessibility since it is available over the counter and ends up being in very high demand. The concern about its indiscriminate use is related to the risks and consequences that can cause various adverse effects, such as blood disorders. It is important to highlight the importance of a pharmaceutical professional so that patients receive appropriate guidance on medication administration. This study aims to present the importance of pharmaceutical care, analyzing the risks of self-medication and the indiscriminate use of dipyrone. The present work was an integrative bibliographic review, where searches were carried out in the LILACS, SciELO, and COCHRANE databases. Dipyrone is a medicine that, when used correctly, is safe. In the results, the publications were concentrated in the year 2022, which presented 4 studies (50%), in 2023, 2 studies (25%), and in 2018 and 2021, only 1 study each year (12.5%). Thus, Pharmaceutical Care plays a crucial role in combating the indiscriminate use of Dipyrone, a medicine widely used to relieve pain and reduce fever. However, if taken in high doses or incorrectly, it can cause unpleasant side effects such as vomiting, nausea, and bloating. Therefore, the pharmacist plays a crucial role in promoting the responsible use of medications, particularly in the case of Dipyrone and other over-the-counter medicines.