USE OF PLATELET-RICH FIBRIN (PRF) IN ORAL SURGERY: A BIBLIOGRAPHIC REVIEW

Abstract

Introduction: Platelet-rich fibrin (PRF) is an autologous blood concentrate obtained by centrifuging whole blood without anticoagulants. It forms a fibrin matrix that entraps platelets, leukocytes, and growth factors, which are slowly released to promote angiogenesis and tissue regeneration. Clinically, PRF accelerates softtissue healing, preserves alveolar bone, and modulates inflammation, while offering the safety of an autologous product and the convenience of “chair-side” preparation. Objective: To systematize in an integrative literature review the preparation protocols, biological mechanisms, and main clinical applications of PRF in dental surgery published between 2015 and 2025. Methods: We searched SciELO, PubMed/MEDLINE, Web of Science, SpringerLink, and MDPI using the terms “platelet-rich fibrin” OR “fibrina rica em plaquetas” combined with “oral surgery” OR “cirurgia bucal,” filtering for publications from 2015 to 2025 in Portuguese, English, and Spanish. Expected results: Study selection followed the PRISMA flowchart, and two independent reviewers extracted and thematically organized the data into five categories: definition and processing, centrifugation protocols, biological mechanisms, clinical applications, and future perspectives.