EFFICACY OF CUSTOMIZED COMPOUNDED MEDICATIONS FOR CONDITIONS SUCH AS DIABETES AND AUTOIMMUNE DISEASES

Abstract

INTRODUCTION: Personalized therapy using compounded medications has emerged as a relevant strategy in the treatment of chronic diseases, such as diabetes mellitus and autoimmune diseases. This approach allows for the individualization of pharmacological care, permitting dose adjustments, combination of active ingredients, and adaptation of pharmaceutical forms according to the specific needs of each patient. In this context, the importance of therapeutic personalization stands out as a factor that can contribute to improved clinical outcomes, greater adherence to treatment, and more effective control of chronic conditions. METHODS: This is an integrative literature review, with a qualitative and descriptive approach. Data collection was carried out in the PubMed, SciELO, and LILACS databases, using the descriptors pharmaceutical preparations, diabetes mellitus, and autoimmune diseases, combined by the Boolean operator AND. RESULTS AND DISCUSSION: Articles published between 2016 and 2026, available in full text, in Portuguese and English, were included. The results showed that therapeutic efficacy in chronic diseases is strongly associated with personalized treatment based on biomarkers, genetics, phenotype, and immunological profile, more than with standardized medication. Individualized strategies were observed to contribute to better clinical control, greater therapeutic adherence, and a reduction in complications. CONCLUSION: It is concluded that the efficacy of personalized compounded medications is mainly related to therapeutic individualization, with personalized medicine being a determining factor for better health outcomes. However, the need for more specific clinical studies and greater technical rigor in pharmaceutical compounding to ensure safety and effectiveness is highlighted.