THE AESTHETIC PHARMACIST IN THE USE OF HYALURONIC ACID: APPLICATIONS IN AESTHETICS, RHEOLOGICAL PROPERTIES, AND MANAGEMENT OF COMPLICATIONS WITH HYALURONIDASE

Abstract

Introduction: Due to its biocompatibility, water retention capacity, and clinical predictability, hyaluronic acid (HA) has become one of the most widely used biomaterials in minimally invasive aesthetic procedures. Objective: This study focused on the applications of hyaluronic acid in aesthetics, its rheological properties, and the management of complications with hyaluronidase, always from the perspective of evidence-based pharmaceutical practice. Methodology: This is an integrative literature review of a descriptive and exploratory nature, with a qualitative approach, conducted using the PubMed and SciELO databases. Controlled descriptors (MeSH) and free terms were used, combined with Boolean operators. Articles published between 2021 and 2026, in Portuguese, English, and Spanish, and available in full text were selected, resulting in a final sample of 12 studies. Results: The findings indicated that rheological factors such as elastic modulus (G’), viscosity, and cohesivity are crucial in filler selection, directly influencing tissue support, integration, and clinical safety. It was observed that injection technique, pressure control during administration, and anatomical knowledge are essential to prevent complications. Conclusion: Although adverse events are uncommon, vascular complications require early recognition and immediate intervention, with hyaluronidase standing out as the main reversal agent. Therefore, pharmaceutical practice in aesthetics must be grounded in rigorous scientific evidence, at the intersection of material science and applied clinical practice, as well as in continuous professional training, always aiming at therapeutic efficacy and patient safety.