ADHD AND BINGE-EATING DISORDER: NEUROBIOLOGICAL INTERFACES AND THERAPEUTIC IMPLICATIONS OF LISDEXAMFETAMINE – AN INTEGRATIVE REVIEW

Abstract

Attention-deficit/hyperactivity disorder (ADHD) and binge-eating disorder (BED) present a strong clinical association, sharing mechanisms related to impulsivity, executive dysfunction, and alterations in the brain reward system. This study aimed to analyze the neurobiological interfaces between ADHD and BED, as well as to evaluate the therapeutic effects of lisdexamfetamine in adults with these conditions. This is an integrative literature review conducted through a search in the PubMed database using descriptors related to ADHD, BED, impulsivity, reward system, and lisdexamfetamine. Studies published within the last 10 years involving adults diagnosed with ADHD and/or BED were included. After applying the eligibility criteria, 9 studies composed the final sample. The findings demonstrated shared neurobiological alterations between the disorders, especially in circuits associated with inhibitory control and reward processing. Lisdexamfetamine was associated with reduced binge-eating episodes, improvement in impulsivity, executive functions, and ADHD symptoms, in addition to contributing to weight reduction. It is concluded that lisdexamfetamine represents a relevant therapeutic strategy in the  management of ADHD and BED, although further studies are still needed to evaluate its long-term effects.