BENEFITS AND LIMITATIONS OF DENGUE VACCINATION IN BRAZIL: A SYSTEMATIC REVIEW

Abstract

This study consists of a systematic literature review that evaluates the benefits and limitations of dengue vaccination in Brazil after its incorporation into public immunization programs. Scientific databases and official national documents were searched to identify observational studies, clinical trials, and epidemiological reports that investigated the effectiveness, safety, and population impact of the vaccine, especially in eligible age groups. The outcomes analyzed included disease incidence, severe forms, hospitalizations, deaths, and possible indirect effects in unvaccinated groups. Operational factors related to implementation were also evaluated, such as vaccination coverage, eligibility criteria, dose availability, and integration with vector control measures. In general, the studies indicate a consistent reduction in symptomatic cases and hospitalizations in vaccinated populations, although limitations related to the duration of protection, regional heterogeneity of viral circulation, and logistical challenges to expanding coverage persist. No evidence of a relevant increase in severe forms was identified in individuals adequately eligible for vaccination. It is concluded that dengue vaccination represents an important complementary tool for vector control, but its population effectiveness depends on integrated strategies of epidemiological surveillance, logistical planning, and continuous safety monitoring.