FAT GRAFT ENRICHED WITH SVF/PRP: EVIDENCE OF INTEGRATION, VOLUME RETENTION, AND SAFETY

Abstract

Introduction: Autologous fat grafting enriched with vascular stromal fraction (VSF) and platelet-rich plasma (PRP) has been investigated as a strategy to improve tissue integration and volume retention. It was observed that VSF contributed to angiogenesis and regeneration, while PRP provided growth factors that stimulate neovascularization. This combination aimed to reduce limitations such as reabsorption and necrosis, particularly in women undergoing breast reconstruction and aesthetic corrections. As pointed out by Koca, Karabekmez, and Yilmaz (2019, p. 1268), "enriching adipose grafts with VSF and PRP significantly increased graft survival and local vascularization." Objective: This literature review analyzed the evidence on integration, volume retention, and safety of grafts enriched with VSF and PRP. Methodology: A literature review based on the PRISMA checklist was conducted, searching the PubMed, SciELO, and Web of Science databases, including articles published in the last 10 years, using the descriptors "fat grafting," "stromal vascular fraction," "platelet-rich plasma," "fat graft survival," and "adipose tissue transplantation"; clinical and experimental studies with volume retention assessment were included, and studies with small sample sizes, lack of quantitative analysis, and inconsistent methodology were excluded. Results: Increased graft survival, greater vascularization, and less reabsorption were evidenced, in addition to improved tissue quality and a low incidence of complications. Conclusion: It was concluded that the technique showed promise regarding integration, volume retention, and safety.