IN VITRO FERTILIZATION AS AN ALTERNATIVE FOR CASES OF INFERTILITY IN MEN AND WOMEN WITH HUMAN PAPILLOMAVIRUS

Abstract

Human Papillomavirus (HPV) infection is widely known for its association with neoplasia, but recent studies have shown its negative influence on the fertility of men and women, interfering with the results of natural and assisted fertilization. Therefore, this study aimed to analyze the viability of in vitro fertilization (IVF) as an alternative for infertile couples diagnosed with HPV, investigating the impacts of the virus on gametes, IVF outcomes, and complementary strategies used in these cases. This is a literature review, with searches carried out in the SciElo, PubMed, Scopus, and Web of Science databases, including publications between 2020 and 2025. The results indicated that HPV is associated with changes in sperm and oocyte quality, inflammation of the reproductive tract, and reduced implantation, fertilization, and live birth rates. Furthermore, the adoption of complementary protocols such as viral screening, gamete selection and immunological control proved to be relevant to mitigate the effects of infection. It is concluded that IVF, associated with specific strategies, represents a promising alternative for patients with HPV.