INTERACTIONS BETWEEN NEUROPHARMACOLOGICAL AGENTS AND SURGICAL INTERVENTIONS IN THE MANAGEMENT OF TRIGEMINAL NEURALGIA

Abstract

Trigeminal neuralgia is a neuropathic condition characterized by severe and recurrent facial pain that significantly affects patients’ quality of life. This study aimed to analyze the impact and interactions of neuropharmacological agents in surgical interventions associated with the treatment of this condition. An integrative literature review was conducted based on studies published between 2016 and 2026 in health science databases. The findings indicate that anticonvulsants such as carbamazepine, oxcarbazepine, and gabapentin represent the first-line treatment; however, some patients present limited response or adverse effects. In such cases, surgical interventions, including microvascular decompression and percutaneous procedures, appear as effective alternatives for pain control. The analysis also suggests that the continued use of neuropharmacological agents may influence perioperative management and clinical outcomes. It can be concluded that integrating pharmacological and surgical therapies, together with a multidisciplinary approach, is essential to optimize treatment and improve the prognosis of patients with trigeminal neuralgia.