THROMBOPHILIA: A CLINICAL CHALLENGE IN PREGNANCY AND ITS IMPLICATIONS FOR PHARMACEUTICAL CARE

Abstract

Introduction: Thrombophilia is a clinical condition characterized by a predisposition to thromboembolic events, which during pregnancy becomes a significant challenge for maternal-fetal health. The physiological state of hypercoagulability in pregnancy, associated with hereditary or acquired factors, increases the risk of complications such as recurrent miscarriages, intrauterine growth restriction, preeclampsia, and thromboembolic events. Objective: To analyze gestational thrombophilia and its implications for pharmaceutical care. Methodology: An integrative literature review with a qualitative and descriptive approach, conducted in databases such as SciELO, PubMed, and Google Scholar, considering publications between 2023 and 2025. The results highlight the importance of pharmaceutical practice in monitoring anticoagulant pharmacotherapy, preventing drug interactions, and promoting educational strategies. It is concluded that the pharmacist’s participation in multiprofessional teams contributes to greater maternal-fetal safety and better treatment adherence. Development: The study addressed the main types of thrombophilia, diagnostic methods, pharmacotherapeutic strategies with anticoagulants, and the pharmacist’s role within the multidisciplinary team. Actions related to pharmacovigilance, health education, and therapeutic adherence were discussed as essential pillars for effective and safe treatment. Conclusion: Pharmaceutical care is indispensable in preventing complications and promoting health during pregnancy. The pharmacist’s presence contributes to the rational use of medicines, reduces the risk of thrombotic events, and ensures greater adherence to treatment. This integrated and humanized approach strengthens the safety of the mother–fetus binomial and consolidates the importance of this professional in obstetric care.