PARACETAMOL-INDUCED LIVER TOXICITY: MECHANISMS AND PREVENTION STRATEGIES IN PHARMACEUTICAL CARE

Abstract

Paracetamol is a widely used medication, but its excessive use can lead to severe liver toxicity. Its toxicity is a significant public health problem, with serious consequences for patients' health and substantial economic impacts on health systems. This article aims to conduct a literature review on liver toxicity caused by paracetamol, addressing the drug's mechanisms of action, pharmacokinetics, pharmacodynamics, safe daily dose, and side effects. The pharmacist's role in preventing paracetamol abuse will also be highlighted, including a set of clear and accurate information on the safe use of the medication and dose monitoring. The methodology used was a literature review based on material published in scientific articles. The conclusion of this analysis aims to contribute to the understanding of paracetamol toxicity and to the development of effective prevention and treatment strategies. Strengthening pharmaceutical care practices, coupled with the active participation of health professionals and the pharmaceutical industry in promoting the rational use of paracetamol.