RELATIONSHIP BETWEEN HYPERGLYCEMIA CAUSED BY TYPE 2 DIABETES MELLITUS AND ALZHEIMERS´S

Abstract

Type 2 Diabetes Mellitus (DM2) is characterized by insulin resistance, which leads to increased blood glucose levels. Alzheimer's disease (AD) is a pathology that causes brain neurodegeneration due to the accumulation of beta-amyloid peptides in neurons. The relationship between DM2 and AD occurs because the insulin resistance caused by DM2 generates chronic inflammation that can contribute to neuronal degeneration. So how is Type 2 Diabetes Mellitus linked to Alzheimer's disease? This article aims to describe the causes of Type 2 Diabetes, how neuronal degeneration occurs in Alzheimer's disease, and what the links are between the two disorders. The purpose of this research is to understand the link between type 2 diabetes mellitus and Alzheimer's disease, contributing to the study of diseases frequently seen in the population today. As a methodology, a literature review was carried out in order to synthesize information and elucidate the topic addressed, this information was collected from the selection of articles, magazines, books, websites, in different languages, ensuring varied points of view. As a result of this research, it was possible to understand the reasons for the development of Type 2 Diabetes Mellitus, how neuronal degeneration caused by Alzheimer's occurs and how insulin insufficiency can lead to neurodegeneration.