THE ANTI-DOUBLE STRANDED DNA AND THE JOINT MANIFESTATIONS IN SYSTEMIC LUPUS ERYTHEMATOSUS: ANALYSIS OF LABORATORY AND CLINICAL CORRELATION IN PATIENTS FROM AN INSTITUTION OF WESTERN PARANÁ

Abstract

Systemic Lupus Erythematosos (SLE) is a complex autoimmune condition characterized by a variety of clinical manifestations, with musculoskeletal alterations being among the most prevalent, especially in women. This study aimed to analyze the correlation between the presence of anti-double-stranded DNA and such alterations in patients with SLE, with the intention of contributing to the clinical management of the disease. The methodology used was a quantitative, retrospective, and observational analysis of medical records from a Rheumatology clinic in Cascavel, Paraná, collecting data from 54 patients diagnosed with SLE between 2019 and 2023. The variables analyzed were patients with SLE, the presence of articular manifestations, and the presence of anti-double-stranded DNA. The results indicated that 66,7% of the patients with articular manifestations tested positive for anti-double-stranded DNA, reinforcing the correlation between this marker and the incidence of joint issues. Although some patients with arthritis did not present this antibody, the research showed that the presence of anti-double-stranded DNA may be associated with a higher risk of musculoskeletal manifestations. The findings highlight the importance of an individualized approach in managing SLE and suggest the need for further research to explore other manifestations and their interactions with immunological markers.