THE ASSOCIATION OF THROMBOPHILIA WITH GESTATIONAL PRE-ECLAMPSIA

Abstract

Introduction: This study associates thrombophilia with gestational preeclampsia. The gestational period is a condition prone to the emergence of thromboembolic disease due to the state of blood hypercoagulability, which can result in reduced blood flow in the lower limbs. Preeclampsia has been associated with thrombophilia in some cases, therefore, it is necessary to monitor and treat this condition appropriately, as it can pose risks to the mother and the baby. Objective: to analyze the relationship between thrombophilia and preeclampsia during pregnancy. Methodology: This is an integrative review, which has as its guiding question “What is the relationship between thrombophilia and preeclampsia during pregnancy?” Thus, the following question was formulated: “What is the relationship between thrombophilia and preeclampsia during pregnancy?”. The inclusion criteria used to select the studies were articles published in the last 5 years, in English and Portuguese, available free of charge, excluding duplicate articles, other reviews and gray literature. The studies were selected from the Virtual Health Library (BVS), Scientific Electronic Library Online (Scielo) and PubMed. The descriptors used were selected from the Health Sciences Descriptors (DeCS) and Medical Subject Headings (MeSH) platforms, namely: “Thrombophilia”, “Gestação” and “Pré-Eclâmpsia”, in Portuguese; “Thrombophilia”, “Pregnancy” and “Pre-Eclampsia”, in English, the Boolean operator AND will be used. The search for articles will be carried out during the months of July and August 2024. Fourteen articles were included for analysis. Results: The association between thrombophilia and PE has been widely studied due to the significant impact of these conditions on maternal and fetal health. Thrombophilias, hereditary or acquired predispositions for vascular thrombosis, have been associated with obstetric complications, such as recurrent miscarriages, fetal death and severe preeclampsia. Final considerations: Hereditary and acquired thrombophilias are associated with adverse obstetric outcomes, such as severe preeclampsia, HELLP syndrome and recurrent miscarriages.