PARASITE RESISTANCE TO ANTHELMINTICS AND ONE HEALTH: CHALLENGES AND OPPORTUNITIES IN INTEGRATING HUMAN AND ANIMAL HEALTH APPROACHES

Abstract

Parasitic resistance to anthelmintics is a growing phenomenon that poses a significant challenge to the control of parasitic diseases in humans and animals. The indiscriminate and improper use of these medications has contributed to the selection of resistant parasites, compromising the effectiveness of conventional therapies. In the context of One Health, which integrates human, animal, and environmental health approaches, this issue becomes even more complex, as parasites can affect both human and animal populations, with economic, ecological, and social implications. For this study, the methodology adopted was a bibliographic review of published scientific articles on parasitic resistance, One Health, and the impact of anthelmintics, considering the interactions between human and animal health. The research focused on analyzing the main control strategies, the mechanisms contributing to resistance, and possible alternative approaches to treatment and prevention. The results indicate that resistance is mediated by factors such as genetic mutations, selective pressure caused by improper drug use, and the lack of integrated management strategies. Moreover, resistance to anthelmintics has direct consequences on public and veterinary health, affecting the control of parasitic diseases in various species. The conclusion highlights the urgent need for integrated management based on One Health to effectively address this problem. Raising awareness about the rational use of anthelmintics and the development of new therapeutic approaches are essential to mitigate the impacts of parasitic resistance and ensure the control of parasites in humans and animals.