EVALUATION OF GENETIC AND ENVIRONMENTAL FACTORS IN PREDISPOSITION TO CHILDHOOD LEUKEMIA - A LITERATURE REVIEW

Abstract

Childhood leukemia is a multifactorial disease influenced by genetic and environmental factors. Genetic analysis reveals predisposition in certain individuals, highlighting genetic mutations as significant risk factors. Additionally, environmental exposures such as radiation and chemicals are also associated with the causes of this disease. The combination of these factors can trigger childhood leukemia, posing a significant challenge to public health. This study investigates the gene-environment relationship through the analysis of scientific articles, exploring epidemiological studies, genomic association, environmental exposure, and systematic reviews. Databases such as PubMed, Scielo, and Google Scholar were used, employing keywords such as childhood leukemia, genetic factors, environmental factors, and gene-environment interactions. The results provide a comprehensive view of the relative contribution of these factors to the development of childhood leukemia, also discussing the underlying biological mechanisms of gene-environment interactions and their clinical and public health implications. Better understanding of these influences can contribute to the development of more effective preventive and therapeutic strategies to mitigate the impact of childhood leukemia.