HEPATOPROTECTIVE EFFECT OF COFFEE ON THE PROGRESSION OF FIBROSIS ASSOCIATED WITH CHRONIC HEPATIC DISEASE

Abstract

Introduction: Advanced chronic liver disease represents the final stage of hepatocyte damage, leading to portal hypertension and liver failure and its complications. Liver cirrhosis, the histological diagnosis of this condition, represents one of the main causes of mortality globally. Objective: this study aims to evaluate the hepatoprotective potential of coffee consumption in the progression of chronic liver diseases. Methodology: this is a systematic review of the literature. The research included searching for articles related to coffee consumption and chronic liver disease in the PubMed and Virtual Health Library databases, using MeSH descriptions. Results: 310 articles were identified, of which 15 were selected for analysis and composition of results. Coffee, rich in caffeine and chlorogenic acid, has antifibrotic and antioxidant properties that can reduce liver fibrosis. Coffee can act through several mechanisms, such as modulating the intestinal microbiota, inducing antioxidant genes and inhibiting adenosine receptors in hepatic stellate cells, which play a crucial role in fibrogenesis. However, results in the literature are varied and may be related to the dosage and composition of the coffee. Final Considerations: Moderate coffee consumption appears to be associated with hepatoprotective effects, including reduced liver fibrosis. However, the relationship between coffee consumption and liver conditions requires additional studies to precisely determine its benefits in the prevention and progression of chronic liver diseases, as there are gaps in determining effective doses in humans.