CORRELATION OF THE INTESTINAL MICROBIOME IN DYSBIOSES INVOLVING PATIENTS WITH AUTISTIC SPECTRUM DISORDER

Abstract

Objective: understand the correlation between the intestinal microbiome and the development of dysbiosis in patients with ASD. Literature Review: ASD is an abbreviation for autism spectrum disorder and is a neurological change that influences communication, behavior and interests/activities. No defined causes have been found for this condition, and it can be diagnosed at an early age. Studies indicate that there is a correlation between the alteration of the microbiota in ASD through intestinal dysbiosis and that individuals with autism can manifest disharmony in the intestinal microbiota compared to individuals without a diagnosis of autism. There is the assumption that ASD can develop from any disturbance that alters the balance of the microbiota-gut-brain axis and the failure of a single part of this mechanism can eventually impact any junction in the chain. Final considerations: The studies do not report any proven pharmacological treatment that resolved the aspect of ASD, however, the symptoms were alleviated when an antibiotic was administered to treat intestinal inflammation, and it was observed that several behavioral and communicative deficits obtained a significant improvement, however, after interrupting the therapeutic regimen, the symptoms returned.