MANGIFERA INDICA L. AND ITS PHARMACEUTICAL APPLICATIONS: AN INTEGRATIVE REVIEW ON PHYTOCHEMISTRY, PHARMACOLOGY, PHYTOTHERAPY, SAFETY, AND TECHNOLOGICAL APPLICATIONS

Authors

  • Daiane Santos Modesto UNIESAMAZ
  • Luciana de Cássia Macedo Costa UNIESAMAZ
  • Patrícia Nogueira Barata
  • Juan Gozanlo Bardalez Rivera Federal University of Para image/svg+xml
  • Gleicy Kelly China Quemel UNIESAMAZ

DOI:

https://doi.org/10.51891/rease.v12i10.30951

Keywords:

Mangiferin, Secondary metabolites, Pharmacological activity, Toxicity

Abstract

This article aimed to analyze the scientific evidence on Mangifera indica L. and its pharmaceutical applications, focusing on its phytochemical composition, pharmacological activities, phytotherapy, safety, toxicity, and technological potential. An integrative, descriptive, and qualitative literature review was conducted using the PubMed/MEDLINE, Scopus, Web of Science, ScienceDirect, SciELO, LILACS, and BVS databases, considering publications from 2016 to 2026. A total of 45 studies were selected and analyzed regarding the main bioactive compounds, biological activities, therapeutic applications, and safety aspects. The results demonstrated broad phytochemical diversity, particularly phenolic compounds, flavonoids, tannins, benzophenones, and mangiferin, mainly associated with antioxidant, anti-inflammatory, antimicrobial, antidiabetic, gastroprotective, and cardioprotective activities. Technological applications involving nanoemulsions, nanoparticles, functional foods, and the valorization of by-products were also identified. Safety evidence was variable, reinforcing the importance of evaluating doses and preparations. It is concluded that M. indica has significant pharmaceutical and phytotherapeutic potential, although further clinical and toxicological studies are needed

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Author Biographies

  • Daiane Santos Modesto, UNIESAMAZ

    Discente do curso de Bacharelado em Farmácia do Centro Universitário da Amazônia (UNIESAMAZ).

  • Luciana de Cássia Macedo Costa, UNIESAMAZ

    Discente do curso de Bacharelado em Farmácia do Centro Universitário da Amazônia (UNIESAMAZ).

  • Patrícia Nogueira Barata

    Discente do curso de Bacharelado em Farmácia do Centro Universitário da Amazônia (UNIESAMAZ).

  • Juan Gozanlo Bardalez Rivera, Federal University of Para

    Doutor e Mestre em em Patologia das Doença Tropicais pelo Núcleo de Medicina Tropical da Universidade Federal do Pará, graduado em farmácia pelo Centro de Ensino Superior do Pará. (Co-orientador). Farmacêutico da Secretaria Municipal de Saúde (SESMA/ Belém).

  • Gleicy Kelly China Quemel, UNIESAMAZ

    Mestre em Ciências Ambientais pela Universidade do Estado da Amazônia e Graduada em Ciências Naturais com Habilitação em Química pela Universidade Federal do Pará. (Orientadora). Docente do Centro Universitário da Amazônia (UNIESAMAZ).

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Published

2026-10-20

Issue

Vol. 12 No. 10 (2026): Revista Ibero-Americana de Humanidades, Ciências e Educação — REASE

Section

Artigo de Revisão

Categories

License

Atribuição CC BY

 

How to Cite

Modesto, D. S., Costa, L. de C. M., Barata, P. N., Rivera, J. G. B., & Quemel, G. K. C. (2026). MANGIFERA INDICA L. AND ITS PHARMACEUTICAL APPLICATIONS: AN INTEGRATIVE REVIEW ON PHYTOCHEMISTRY, PHARMACOLOGY, PHYTOTHERAPY, SAFETY, AND TECHNOLOGICAL APPLICATIONS. Revista Ibero-Americana de Humanidades, Ciências E Educação, 12(10), 1-35. https://doi.org/10.51891/rease.v12i10.30951

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