ADVANCES IN BIOLOGICAL THERAPIES FOR NEUROSURGICAL ANESTHESIA: A NARRATIVE REVIEW OF MONOCLONAL ANTIBODIES AND GENE THERAPY APPLICATIONS IN BRAIN TUMOR MANAGEMENT AND NEURODEGENERATIVE DISEASES

Abstract

Neurosurgical anesthesia has seen significant progress with the introduction of biological therapies, particularly monoclonal antibodies and gene therapy. These novel treatments hold immense potential in the management of complex neurological conditions, notably brain tumors and neurodegenerative diseases. The promise of monoclonal antibodies that target specific antigens as adjuvant therapies for aggressive malignancies like glioblastoma, and gene therapy's objective to correct genetic abnormalities responsible for various neurological disorders, are particularly noteworthy. This narrative review aims to provide a comprehensive overview of the current research, challenges, and future directions of these biological therapies in the context of neurosurgical anesthesia.