IMPACT OF CURCUMIN ON THE REGULATION OF OXIDATIVE STRESS AND INFLAMMATION IN INDIVIDUALS WITH TYPE 2 DIABETES: A SYSTEMATIC REVIEW

Abstract

Type 2 diabetes is a chronic disease characterized by abnormal glucose metabolism, resulting in high blood sugar levels. Furthermore, this condition is associated with oxidative stress and inflammation, processes that play an important role in the progression of the disease and the development of complications. Curcumin, a polyphenol found in turmeric, has been widely studied due to its antioxidant and anti-inflammatory properties. This systematic review aims to evaluate the impact of curcumin on the regulation of oxidative stress and inflammation in individuals with type 2 diabetes. Electronic databases were searched, including PubMed, Scopus and Web of Science, selecting studies published in the last 10 years. Several experimental and clinical studies were included in this review. The results of the studies showed that the use of curcumin was able to significantly reduce markers of oxidative stress, such as malondialdehyde and hydrogen peroxide, in individuals with type 2 diabetes. Furthermore, it was observed a decrease in the levels of pro-inflammatory cytokines such as TNF-α and IL-6 after curcumin supplementation. Furthermore, curcumin has been shown to be effective in improving metabolic parameters such as blood glucose, glycated hemoglobin and insulin resistance. Studies have also suggested that curcumin may exert a beneficial effect in preventing micro- and macrovascular complications associated with type 2 diabetes. In conclusion, this systematic review highlights the potential of curcumin as a therapeutic agent in regulating oxidative stress and inflammation in individuals with diabetes. type 2. However, further studies are needed to determine the ideal doses and the mechanisms of action involved.