ADVANCES AND NEW PERSPECTIVES IN THE MANAGEMENT OF CROHN'S DISEASE: A LITERATURE REVIEW

Abstract

Crohn's disease (CD) is a chronic, immune-mediated, and progressive inflammatory bowel disease associated with significant clinical burden and reduced quality of life. In recent years, advances in understanding its pathophysiology have driven the development of more effective diagnostic and therapeutic strategies based on precision medicine and individualized treatment. This study aimed to analyze the most recent scientific evidence regarding advances and future perspectives in the management of CD, emphasizing diagnostic innovations, biomarkers, artificial intelligence, biologic therapies, small molecules, and precision medicine approaches. An integrative literature review was conducted using the PubMed and Virtual Health Library (VHL) databases, employing the descriptors "Crohn Disease," "Therapeutics," and "Precision Medicine," combined with the Boolean operator AND. Studies published between 2021 and 2026, available in full text and related to the proposed topic, were included. The evidence demonstrated that the incorporation of molecular biomarkers, artificial intelligence-based technologies, and novel targeted therapies has enhanced the ability to predict therapeutic response, optimize clinical decision-making, and support individualized treatment strategies. In conclusion, recent advances have significantly transformed the management of Crohn's disease, establishing precision medicine as a promising approach to improve clinical outcomes and patients' quality of life.