ANALYSIS OF CLINICAL OUTCOMES OF INTRAVENOUS THROMBOLYSIS IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Abstract

The objective of this study was to analyze the clinical outcomes of hospitalizations for ischemic stroke in the state of Paraná, Brazil, from 2021 to 2025, with emphasis on the use of intravenous thrombolysis. This is an ecological, observational, retrospective study with a quantitative approach, based on secondary data obtained from the Department of Informatics of the Unified Health System through the Hospital Information System. Variables such as the number of hospitalizations, in-hospital mortality rate, and use of thrombolysis were analyzed. During the study period, 7,304 hospitalizations and 928 deaths were recorded, with a reduction in mortality from 14.6% in 2021 to 10.4% in 2025. The rate of thrombolysis use increased from 20.2% to 34.8% over the same period. The findings demonstrate an expansion in the use of thrombolytic therapy concomitant with improvements in hospital indicators. It is concluded that increased access to thrombolysis and improvements in healthcare network organization may be associated with better clinical outcomes in the management of ischemic stroke within the public health system.