ASSOCIAÇÃO ENTRE CONTRACEPÇÃO HORMONAL E O RISCO DE NEOPLASIAS UTERINAS: UMA REVISÃO SISTEMÁTICA

Eduarda Alves de Abreu; Ana Helena Cardoso Reis; Ana Beatriz dos Santos Medeiros; Beatriz Barreira Rocha; Cecília Marques Soares; Rafaella Cruz Sodré; Manuela Gambardello de Souza Oliveira; Isabella Ferrarezi Mota; Erica Eugenio Lourenco Gontijo

doi:10.51891/rease.v12i6.27690

Authors

Eduarda Alves de Abreu UnirG
Ana Helena Cardoso Reis UnirG
Ana Beatriz dos Santos Medeiros UnirG
Beatriz Barreira Rocha UnirG
Cecília Marques Soares UnirG
Rafaella Cruz Sodré UnirG
Manuela Gambardello de Souza Oliveira UnirG
Isabella Ferrarezi Mota UnirG
Erica Eugenio Lourenco Gontijo UnirG

DOI:

https://doi.org/10.51891/rease.v12i6.27690

Keywords:

Hormonal Contraception. Uterine Neoplasms. Systemic Effects.

Abstract

The aim of the study is to analyze the association between hormonal contraception and the risk of uterine neoplasms. For this, a systematic review was carried out in the PubMed, Scopus, Web of Science and Embase bases, with publications between 2021 and 2026, following the PICO strategy, the PRISMA guidelines and has registration in PROSPERO under the code CRD420261368414. Four cohort observational studies were included, evaluated by the NHLBI questionnaire to analyze the risk of bias. Given this, the results showed that the intrauterine device releasing levonorgestrel reduced the risk of endometrial cancer by 33% and cervical cancer by 9%, but increased the risk of breast cancer by 13%. In addition, IUD use was associated with a lower risk of severe cervical lesions compared to combined oral contraceptives (COCs), which showed an inverse association with myomas and long-lasting endometrial protection. It is concluded that hormonal contraception exerts a dual biological pathway, promoting robust endometrial and ovarian protection, but requiring cervical and mammary surveillance, especially for COCs.