SPOROTHRIX RESISTANCE GENES, PROTEOMIC RESPONSES AND ALTERNATIVE THERAPIES IN SPOROTRICHOSIS: A NARRATIVE REVIEW

Abstract

Sporotrichosis is a zoonotic disease caused by species of the fungus Sporothrix. Currently, the main treatment is conventional antifungals such as itraconazole, potassium iodide, amphotericin B, and others. However, several reports demonstrate increased fungal resistance to the drugs used, as well as adverse effects in patients such as apathy, anorexia, fever, etc. Therefore, this study is a review of articles published between 2019 and 2025, addressing the resistance genes of Sporothrix spp., proteomic response in the presence of medications, and alternative treatments for sporotrichosis. A search was conducted on the SCOPUS, Web of Science, PubMed, and Google Scholar platforms. Theses and dissertations, review articles, and works not directly related to the proposed topic were excluded from the review. Thus, six articles on resistance genes, five articles on proteomic response, and seven studies on alternative treatments for mycosis were selected. It is important to note that further studies should be conducted to deepen the understanding of this subject, and it is hoped that this review will serve as a basis for future work and initiatives.