PREVALENCE AND MORTALITY OF CERVICAL CANCER ACCORDING TO THE REPRODUCTIVE STAGES OF STRAW+10: AN INTEGRATIVE REVIEW

Abstract

The aim of this study was to evaluate whether there are differences in the prevalence and mortality from cervical cancer (CCU) between the phases of female reproductive aging, based on the physiological criteria of the STRAW+10 system. The mapping was conducted using the average age of women described in each selected article, seeking to reconcile the different age ranges and distribute them across the physiological phases defined by the system: pre-menopause, menopausal transition, and post-menopause. The results showed a higher concentration of cases and deaths in the transition and post-menopausal phases (50-59 years), periods of endocrine instability and follicular depletion, in which the reduction of estrogen and the increase in FSH compromise the immune response. Complementary evidence indicated immune variations associated with the cytokine TGF-β, which favor the progression of HPV to invasive forms. It is concluded that the post-transition stage was the most affected by cervical cancer lethality and that the incorporation of STRAW+10 into epidemiological analyses represents a relevant methodological advance for future research and screening policies focused on women's reproductive health.