USE OF VASOPRESSORS IN RESUSCITATION OF PATIENTS WITH SEPTIC SHOCK IN EMERGENCY SETTINGS: AN INTEGRATIVE REVIEW

Abstract

Septic shock is a critical condition characterized by organ dysfunction associated with sepsis and hypotension refractory to fluid replacement, and is one of the main causes of mortality in emergency settings. Vasopressors are essential in hemodynamic resuscitation, contributing to the restoration of tissue perfusion and reduction of adverse outcomes. This study aimed to perform an integrative review of the scientific literature on the use of vasopressors in the resuscitation of patients with septic shock in emergency departments, focusing on efficacy, safety, and management guidelines. The methodology included searches in indexed databases, applying strict inclusion and exclusion criteria. The results show that norepinephrine remains the first-line vasopressor, while agents such as vasopressin and angiotensin II present benefits in refractory cases. Additionally, early initiation of therapy was associated with improved clinical outcomes. However, gaps related to treatment individualization and the impact of therapeutic combinations were identified. It is concluded that, although updated guidelines support the judicious use of vasopressors, more research is needed to optimize therapeutic strategies and minimize associated risks.