METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS A STRAIN OF COMMUNITY HOSPITAL IMPORTANCE

Abstract

Staphylococcus aureus is a bacteria that is part of the skin microbiota in a large part of the population. They mainly colonize the nostrils, generally people carrying this bacteria are asymptomatic and can transmit to other individuals, therefore it is easy to spread and difficult to control. Staphylococcus aureus developed resistance mechanisms which resulted in the modification of proteins in its cell wall, resulting in a protein with changes to PBP2a, responsible for conferring resistance to S.aureus against all beta lactam antibiotics. Nowadays, this bacterium is one of the most important causes of infections in the hospital environment. Vancomycin is among the most used oral drugs, being the standard medication. However, today there are already strains resistant to vancomycin, which is a cause for great concern as they become increasingly resistant to antibiotics, Therefore, it is extremely important that new drugs are manufactured with different mechanisms of action than those already in use.