DIFFERENCE BETWEEN CANNABIDIOL AND DELTA-9-TETRAHYDROCANANABINOL IN THE MANAGEMENT OF CHRONIC PAIN

Abstract

This article analyzes the efficacy of cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) in managing chronic pain, highlighting their differences and similarities in treatment. The theoretical review revealed that isolated CBD shows limited efficacy in reducing chronic pain, often being less effective than conventional treatments. In contrast, the combination of CBD with THC and other cannabinoids, known as the entourage effect, demonstrated more promising results. Studies indicate that preparations with a balanced proportion of CBD and THC can provide significant pain relief due to the synergy between the compounds. In addition to potential benefits, the use of medicinal cannabis, especially with THC, may be associated with significant side effects, such as dizziness, dry mouth, and psychological changes. The presence of THC can induce euphoria, anxiety, and, in extreme cases, temporary psychoses. Although the combination of CBD and THC is generally more effective, it can also increase the incidence of adverse effects, requiring careful monitoring. Therefore, the choice of therapy should be well-informed and personalized, considering the risks and benefits of each compound to optimize therapeutic outcomes in managing chronic pain.