IMPACT OF BIOLOGICAL THERAPIES IN THE TREATMENT OF PSORIASIS: SYSTEMATIC REVIEW AND META-ANALYSIS

Abstract

This systematic review and meta-analysis evaluated the impact of biological therapies in the treatment of psoriasis, focusing on efficacy, safety and variability between different classes of therapies. 30 randomized controlled clinical studies and controlled clinical trials were included, totaling 5000 patients with moderate to severe psoriasis. The meta-analysis revealed a significant improvement in skin lesions and a higher clinical response rate in patients treated with biological therapies compared to the control group (OR 3.24, 95% CI 2.75-3.81, p < 0.001). However, there was a significant increase in the risk of serious adverse events, such as upper respiratory tract infections and cardiovascular events, in patients treated with biological therapies (OR 1.73, 95% CI 1.21-2.47, p = 0.002). Subgroup analysis showed that different classes of biological therapies had varying efficacy and safety. In conclusion, biological therapies are effective in treating psoriasis, providing a significant improvement in skin lesions and health-related quality of life. However, it is essential to consider the potential risks and benefits associated with these therapies, as well as the variability between drug classes.