GENOMIC ANALYSIS OF THE MOST RECURRING RESISTANT BACTERIA RELATED TO HOSPITAL-ACQUIRED PNEUMONIA

Abstract

Infectious diseases are one of the main causes of mortality even today, given this problem, there is an increase in the number of resistant bacteria, mainly associated with hospital infections, where one of the main pathologies developed is the manifestation of pneumonia, whether acquired after hospitalization, or due to the need to use mechanical ventilation. The main resistant bacteria observed in hospital environments are Staphylococcus aureus and Klebsiella pneumoniae, which contain a genomic complex, originating from mutations and horizontal transfers, which enable resistance to various antibiotics. In addition to observing multi-resistance in both bacteria, resulting from the incorporation of one or more genes, which confer resistance to a greater quantity of antibiotics, thus complicating the treatment of patients affected by such bacteria. In this context, it is necessary to analyze the genomic structure, through molecular methods, which contributes to the understanding of the resistance mechanisms of such bacteria and, consequently, allows the elucidation of questions in the physiological, epidemiological and prophylactic areas, as well as contributing for the development of future research into therapeutic measures.