THERAPEUTIC APPROACHES FOR THE MANAGEMENT OF RESISTANT ARTERIAL HYPERTENSION: AN INTEGRATIVE REVIEW

Abstract

Resistant hypertension (RHTN) is a challenging condition characterized by persistent high blood pressure despite treatment with multiple medications. This study performs an integrative review to analyze current therapeutic approaches for the management of RHTN, with emphasis on the efficacy and safety of available strategies. The review covers lifestyle modifications, combination pharmacological therapies, and nonpharmacological interventions such as renal denervation. The results demonstrate that, although lifestyle modifications and combination medications are essential, nonpharmacological interventions emerge as promising options. However, the efficacy of these approaches can vary and adverse effects pose significant challenges. Integration of strategies and personalization of treatment are crucial to improve blood pressure control and quality of life of patients with RHTN.