CELIAC DISEASE AND ENDOCRINE DISORDERS IN CHILDREN: COEXISTENCE AND CLINICAL IMPLICATIONS

Abstract

Introduction:The coexistence of celiac disease and endocrine disorders in children has been a growing concern in pediatric medicine due to the complex interrelationship between these conditions. Recent studies have suggested that the simultaneous presence of these autoimmune diseases reflects an underlying autoimmune phenomenon that affects multiple body systems, impacting children's growth, development and quality of life. Celiac disease, by compromising nutrient absorption, can exacerbate the effects of endocrine disorders such as type 1 diabetes and thyroid disease, resulting in additional complications that require a rigorous and multidisciplinary clinical approach Objective: The objective of this systematic review was to analyze the available scientific literature on the coexistence of celiac disease and endocrine disorders in children, focusing on clinical implications, therapeutic management and impacts on child growth and development. Methodology: The review was conducted based on the PRISMA checklist, using the bases of PubMed, Scielo and Web of Science data. Descriptors employed included "celiac disease," "endocrine disorders," "children," "coexistence," and "growth." Studies published in the last 10 years that addressed the relationship between celiac disease and endocrine disorders in children, with relevant clinical samples, were included. Articles that did not present specific data on the child population, studies with limited samples and those that were not peer reviewed were excluded. Results: The results of the review revealed a significant prevalence of endocrine disorders, especially type 1 diabetes and thyroid dysfunction, in children with celiac disease. The studies analyzed showed that poor nutrient absorption, common in celiac patients, intensified the effects of these disorders, compromising bone development and linear growth. Furthermore, the clinical management of these conditions required a multidisciplinary approach to adjust hormonal treatment and ensure adequate nutrition. Conclusion: The review highlighted that the coexistence of celiac disease and endocrine disorders in children requires continuous clinical surveillance and integrated therapeutic management. Early interventions and a multidisciplinary approach are essential to minimize complications and promote healthy development. The findings reinforce the importance of early diagnoses and continuous monitoring to improve the prognosis and quality of life of these children.