USE OF OXYTOCIN REUPTAKE BLOCKERS IN THE TREATMENT OF ANXIETY

Abstract

Anxiety is a problem faced by many people. The proposal to use oxytocin reuptake blockers (OT) appears as a way to combat anxiety in a way other than benzodiazepines. OT is a nonapeptide synthesized in the paraventricular and supraoptic nuclei of the hypothalamus. When released peripherally by the neurohypophysis, OT acts as a hormone and promotes the release of milk during lactation and uterine contraction during childbirth. However, when released centrally, OT acts as a neurotransmitter or neuromodulator of several processes, such as regulating anxiety and neuroendocrine and cardiovascular responses. Thus, the work aims to evaluate the acute effects of intranasal administration of OT on anxiety in healthy volunteers undergoing the Public Speaking Simulation Test (TSFP) as well as its role in modulating neuroendocrine and hemodynamic responses. Methodology: use of mice with doses of 10ng/h for 5 days and 20ng/h for 7 days to verify the results. Results there was no significant change in acute effects, but there are interesting chronic effects.