REPURPOSING EXISTING MEDICATIONS FOR CHRONIC PAIN MANAGEMENT: A COMPREHENSIVE REVIEW OF MECHANISMS, EFFICACY, AND FUTURE DIRECTIONS

Autores/as

  • Elena Antunes de Vasconcelos EBMSP
  • Julia Coradin Centro Universitário de Pato Branco- UNIDEP
  • Fernanda Leal Caiado Faculdades Unidas do Norte de Minas
  • Afrânio Côgo Destefani EMESCAM
  • Vinícius Côgo Destefani DynMolLab

DOI:

https://doi.org/10.51891/rease.v10i8.15339

Palabras clave:

Chronic Pain. Global Health Burden. Drug Repurposing. Analgesics. Therapeutic. Options.

Resumen

Chronic pain is a major global health issue, affecting around 20% of the adult population in Western countries. Current treatment options often prove inadequate and carry significant side effects, particularly with opioids. Developing new analgesics faces challenges due to difficulties in translating preclinical findings to human outcomes, resulting in clinical trial failures. Considering these obstacles, drug repurposing has emerged as a viable strategy to find new therapeutic options for chronic pain management. This approach investigates existing approved or previously failed drugs for new indications, bypassing the lengthy and costly traditional drug development process. This narrative review provides a comprehensive and in-depth overview of drug repurposing in chronic pain management, examining mechanisms of action, efficacy, and future directions for research and clinical application, ensuring that you, as healthcare professionals, researchers, and individuals involved in chronic pain management, are well-informed and knowledgeable in this area.

Biografía del autor/a

Elena Antunes de Vasconcelos, EBMSP

Escola Bahiana de Medicina e Saúde Pública – EBMSP. 

Julia Coradin, Centro Universitário de Pato Branco- UNIDEP

Centro Universitário de Pato Branco- UNIDEP. 

Fernanda Leal Caiado, Faculdades Unidas do Norte de Minas

Faculdades Unidas do Norte de Minas-Funorte. 

Afrânio Côgo Destefani, EMESCAM

Santa Casa de Misericórdia de Vitoria Higher School of Sciences - EMESCAM Santa Luíza – Vitória – ES – Brazil Molecular Dynamics and Modeling Laboratory (DynMolLab).

Vinícius Côgo Destefani, DynMolLab

Molecular Dynamics and Modeling Laboratory (DynMolLab) Luíza – Vitória – ES – Brazil.

Publicado

2024-08-23

Cómo citar

Vasconcelos, E. A. de, Coradin, J., Caiado, F. L., Destefani, A. C., & Destefani, V. C. (2024). REPURPOSING EXISTING MEDICATIONS FOR CHRONIC PAIN MANAGEMENT: A COMPREHENSIVE REVIEW OF MECHANISMS, EFFICACY, AND FUTURE DIRECTIONS. Revista Ibero-Americana De Humanidades, Ciências E Educação, 10(8), 2990–2999. https://doi.org/10.51891/rease.v10i8.15339