GENETIC AND BIOLOGICAL INSIGHTS INTO NEUROANESTHESIA: IMPLICATIONS FOR ANESTHETIC SAFETY AND THERAPEUTIC INTERVENTIONS IN PATIENTS WITH PRE-EXISTING CEREBRAL INJURY

Authors

  • Beatriz Viana Souto da Silva Unichristus
  • Elena Antunes de Vasconcelos EBMSP
  • Ana Carolina Diniz e Pádua UNIRV
  • Afrânio Côgo Destefani EMESCAM
  • Vinícius Côgo Destefani DynMolLab

DOI:

https://doi.org/10.51891/rease.v10i8.15330

Keywords:

Neuro anesthesia. Genetic insights. Biological mechanisms. Pre-existing cerebral injury. Anesthetic complications.

Abstract

Neuroanesthesia in patients with pre-existing cerebral injury presents unique challenges and potential complications. These challenges underscore the importance of recent advancements in genetic and biological research, which have provided valuable insights into the complex interplay between anesthetics, genomic expression, epigenetic modifications, and molecular mechanisms that contribute to anesthesia-induced neurotoxicity and adverse neurocognitive outcomes. This narrative review explores the current knowledge regarding the genetic and biological factors influencing neuroanesthesia, focusing on patients with pre-existing cerebral injury. By synthesizing findings from preclinical and clinical studies, this review aims to elucidate the mechanisms underlying anesthetic-induced neurodegeneration, genetic predisposition to anesthetic complications, and potential therapeutic interventions to mitigate adverse effects. The implications of these insights for developing safer anesthetic practices and personalized approaches to neuroanesthesia are discussed. Understanding the genetic and biological underpinnings of neuroanesthesia is crucial for optimizing patient care and outcomes in the context of pre-existing cerebral injury.

Author Biographies

Beatriz Viana Souto da Silva, Unichristus

Centro Universitário Christus (Unichristus)

Elena Antunes de Vasconcelos, EBMSP

Escola Bahiana de Medicina e Saúde Pública – EBMSP. 

Ana Carolina Diniz e Pádua, UNIRV

UNIRV- Campus Rio Verde – GO.

Afrânio Côgo Destefani, EMESCAM

Santa Casa de Misericórdia de Vitoria Higher School of Sciences - EMESCAM. Santa Luíza – Vitória – ES Brazil Molecular Dynamics and Modeling Laboratory (DynMolLab)

Vinícius Côgo Destefani, DynMolLab

Molecular Dynamics and Modeling Laboratory (DynMolLab) Santa Luíza – Vitória – ES – Brazil.

Published

2024-08-22

How to Cite

Silva, B. V. S. da, Vasconcelos, E. A. de, Pádua, A. C. D. e, Destefani, A. C., & Destefani, V. C. (2024). GENETIC AND BIOLOGICAL INSIGHTS INTO NEUROANESTHESIA: IMPLICATIONS FOR ANESTHETIC SAFETY AND THERAPEUTIC INTERVENTIONS IN PATIENTS WITH PRE-EXISTING CEREBRAL INJURY. Revista Ibero-Americana De Humanidades, Ciências E Educação, 10(8), 2601–2606. https://doi.org/10.51891/rease.v10i8.15330