PREVALENCE OF INSUFFICIENCY / DEFICIENCY OF VITAMIN D AND ITS RELATIONSHIP WITH CALCIUM AND BIOCHEMICAL PARAMETERS IN PATIENTS WITH CYSTIC FIBROSIS: A REVIEW

Abstract

ABSTRACT: Introduction: The pulmonary impairment is responsible for more than 85% of mortality from cystic fibrosis disease worldwide. People are dying and little has been done about this situation. Objective: Carry out an integrative literature review in order to understand the prevalence of vitamin D insufficiency / deficiency and its relationship with calcium and biochemical parameters in patients with cystic fibrosis. Materials and Methods: It was conducted a literature survey was conducted in April 2020, in the CAPES, Google Scholar and Pubmed databases. The descriptors used were as follows: “Cross-sectional studies” AND “Vitamin D” AND “Cystic fibrosis” AND “Prevalence'' AND “Deficiency”' and “Cross-Sectional Studies AND “Vitamin D' 'AND “Cystic Fibrosis “AND” epidemiology “AND” Avitaminosis' in all databases. The search allowed the identification of four articles that met the established criteria. Results: From the observed data, it was found that in 50% of the articles mentioned that the link with lower levels of vitamin D and pulmonary exacerbations was proven, the other articles could not prove vitamin D deficiency with the worsening of cases of cystic fibrosis. Conclusion: The articles have a low level of evidence, but they suggest that vitamin D deficiency may negatively influence the prognosis of patients affected by cystic fibrosis.