NEW WEAPONS IN GLIOMA TREATMENT, THE MALIGNANT TUMORS OF THE NERVOUS SYSTEM

Abstract

Gliomas are the most common primary brain tumors. It represents a total of 70% of all Central Nervous System neoplasms. Both the diagnosis and the classification of these tumors are based on hispathological features, which are often difficult to define. Despite advances in the field of neurosurgery, chemotherapy and radiotherapy, the prognosis of glioma patients remains very reserved. Over the past two decades, treatment for high-grade gliomas has involved a multidisciplinary approach that relies on maximum surgical resection (when possible), followed by radiotherapy and chemotherapy. This is the conventional therapeutic approach, with a large number of clinical trials showing mostly minor improvements that cannot be considered satisfactory. Thus, this study aims to conduct a literature review with the objective of collecting information on gliomas, as well as advances in diagnosis and treatments. Current options available for glioma treatment are still insufficient and ineffective in controlling disease progression. Encouraging results have appeared in recent experimental studies. They show that the combination of antiangiogenic therapy based on tumor vessel rupture and conventional chemotherapy present satisfactory and unusual results.