EFFECT OF CASEARIA SYLVESTRIS OIL IN CHRONIC INFLAMMATION INDUCED BY SYNTHETIC IMPLANTS IN MICE

Abstract

Inflammation is a natural body’s event that starts immediately when the body suffers a tissue injury. Its goal is to exterminate the noxious agent, however when the noxious agent is not removed and stands much longer, it is succeeded into a chronic inflammation, what is characterized by the persistence of the harmful agent that can go on for days, months or years. When the chronic inflammation ends, it forms a fibrous tissue. This study we evaluated the effect of the essential oil of Casearia sylvestris used on the traditional medicine. Itis rich in a type of chemical class called sesquiterpene, which is characterized for its anti-inflammatory effect. The inflammatory componentwas measured by myeloperoxidase activity (MPO) and N-acetyl-β-D-glicosaminidase (NAG) and mast cells account. For this purpose, 61 male mices C57∕B1∕6 (control group (saline), DMSO1%, 10 ng, 100 ng, and 1000 ng, of C. sylvestris essential oil) underwent to a chronic inflammatory response induced by synthetic sponge and treated with these dosages. The results have showed that the inflammatory component, represented by the evaluation of MPO and NAG activity, had no significant difference between the three doses evaluated compared to the control group. According to the results, the chronic inflammation treated with C. sylvestris essential oil had no effect on the inflammatory process.