MAY ANTIEPILEPTIC DRUGS CAUSE LETHAL, SUBLETHAL, TERATOGENIC EFFECTS AND MORPHOMETRIC ALTERATIONS ON EMBRYOS AND LARVAE OF ZEBRAFISH (DANIO RERIO)? A SYSTEMATIC REVIEW

doi.org/10.29327/217514.7.1-3

Abstract

Objective: The research was carried out for clarify, through a systematic review, the evidence of lethal, sublethal, teratogenic effects and morphometric changes caused by gabapentin, phenobarbital, oxcarbazepine and lamotrigine on embryos and larvae of zebrafish. Methods: The research strategy involved the participation of two researchers who independently evaluated the methodological quality of each papers, available in Pubmed, Science Direct, Google Scholar, Scopus and CAPES journals databases. Results: The research strategy found 07 papers in Pubmed, 228 papers in Science Direct, 2639 papers in Google Scholar, 330 papers in Scopus and 67 papers in CAPES journals totaling 3271 potentially relevant studies in the last 05 years. The 3269 studies were eliminated. Conclusion: According to the results, it was observed that only 2 papers have analyzed any lethal, sublethal or teratogenic effects on zebrafish larvae and larvae. Among them, only gabapentin, phenobarbital and lamotrigine were found in the literature. No studies were found approaching oxcarbazepine. And no work was done in the literature analyzing the morphometry in zebrafish larvae exposed to any antiepileptic.