EFFECT OF PLATELET-RICH FIBRIN (PRF) ON DENTAL IMPLANT OSSEOINTEGRATION: INTEGRATIVE REVIEW

Abstract

Introduction: Contemporary Implantology constantly seeks strategies to minimize the healing period and optimize the bone-implant interface, especially in challenging bone sites. In this context, the use of autologous platelet concentrates, such as Platelet-Rich Fibrin (PRF), emerges as a promising biotechnological alternative due to its ability to release growth factors and cytokines that accelerate angiogenesis and osteogenesis. Methodology: This is an integrative literature review covering publications from 2020 to 2025. Searches were conducted in LILACS, BBO, MEDLINE/PubMed, SCOPUS, and Web of Science databases. Inclusion criteria selected clinical trials, split-mouth studies, and observational studies in humans addressing PRF use in osseointegration. In vitro studies, animal studies, literature reviews, case reports, and articles without clear centrifugation protocols were excluded. The final sample consisted of 47 articles analyzed according to Melnyk and Fineout-Overholt evidence levels. Results: Results demonstrate that PRF application, especially under the low-speed centrifugation concept (LSCC), promotes a statistically significant increase in secondary stability values in the first months. Histological and radiographic analysis confirmed that PRF accelerates bone maturation, preserves alveolar ridge volume, and reduces marginal bone loss, proving as effective as high-cost commercial biomaterials in maxillary sinus lifts and peri-implant gap filling. Conclusion: PRF is a safe, versatile, and low-cost tool that enhances osseointegration and clinical predictability of oral rehabilitations, establishing itself as an essential biological accelerator to optimize tissue repair and aesthetic and functional longevity of dental implants.