METABOLIC ANALYSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS (DM2)

Abstract

Type 2 Diabetes Mellitus, known as T2DM, is a chronic metabolic disease that affects a large part of the population and is mainly related to insulin resistance and increased blood glucose levels. However, this condition does not involve only glycemic changes, as it also causes alterations in lipid metabolism, amino acids, fatty acids and other important substances for the body’s balance. In this context, metabolic analysis, especially through metabolomics, has become an important tool to better understand the biochemical changes present in patients with T2DM. This study aimed to analyze the importance of metabolic analysis in patients with Type 2 Diabetes Mellitus, highlighting its contribution to the identification of biomarkers, early diagnosis, disease monitoring and treatment personalization. The research was carried out through a qualitative bibliographic review, based on scientific articles published between 2016 and 2025, available in databases such as PubMed, SciELO and Google Scholar. The analyzed studies show that patients with T2DM present significant changes in glucose levels, branched-chain amino acids, fatty acids and ketone bodies. It is concluded that metabolomics contributes to a broader and more individualized view of the patient, favoring more preventive, humanized and effective care.