CLINICAL APPLICATIONS OF AMNIOTIC TISSUE IN THE TREATMENT OF CHRONIC WOUNDS: AN INTEGRATIVE LITERATURE REVIEW

Abstract

Introduction: Wounds can be classified as acute or chronic discontinuities affecting any soft tissue of the body, with or without impairment of their primary functions, caused by internal or external factors. In an attempt to reduce healing time, various materials have been used to maintain balance in bacterial activity, creating a favorable environment for tissue repair and reducing or completely treating sequelae. These include activated charcoal, polyurethane film, hydrocolloids, and calcium alginate. However, some of these dressings present contraindications for certain types of wounds, whereas the amniotic membrane does not and can be used to treat all types of wounds. Objective: To analyze the clinical applications of amniotic tissue in the treatment of chronic wounds. Methodology: This research was conducted through an integrative literature review approach. This method involves defining a problem and formulating a hypothesis, with a time frame covering the last seven years (2018 to 2025), using the following databases: SCIELO, LILACS, and PubMed. The keywords used were: chronic wounds, treatment, and amniotic membrane. Conclusion: Chronic wounds represent a significant challenge, especially among vulnerable populations with limited access to healthcare services. The situation becomes even more critical in cases involving burns and traumatic injuries, which require prolonged and specialized care. Although amniotic tissue stands out as a promising alternative in the treatment of chronic wounds, its use still faces challenges related to standardization, clinical validation, and operational feasibility. The literature indicates consistent benefits, but still insufficient evidence for its universal adoption without reservations.