FROM MOLECULE TO PATIENT: EVOLUTION OF PHARMACEUTICAL CARE AND ITS CLINICAL IMPACTS

Abstract

Pharmaceutical practice has evolved from a drug-centered model to a patient-centered approach, driven by the limitations of the traditional model, such as low treatment adherence and a high incidence of adverse events. This transformation reflects changes in health sciences, with greater emphasis on individual patient characteristics in the therapeutic process. This study aims to analyze the scientific evidence regarding the transition from a drug-centered pharmacy model to a patient-centered model, highlighting its impacts on pharmaceutical practice and clinical outcomes. This is an integrative literature review with a qualitative approach, conducted in the databases PubMed, SciELO, and Google Scholar, covering the period from 2015 to 2025. Descriptors related to patient-centered care, clinical pharmacy, and personalized medicine were used. After applying inclusion and exclusion criteria, 42 studies were included in the final sample. The findings demonstrate the expansion of clinical pharmacy, with greater involvement of pharmacists in direct patient care, as well as advances in personalized medicine, particularly through pharmacogenomics. It was also observed that pharmaceutical care significantly improves treatment adherence, reduces adverse events, and optimizes clinical outcomes. It is concluded that pharmacy is undergoing a paradigm shift, in which the focus moves from the drug to the patient as an individualized biological system. This transition promotes greater therapeutic effectiveness, although it still requires more robust and standardized studies for consolidation.