EVALUATION OF THE USE OF COLLAGEN BIOSTIMULATORS IN THE TREATMENT OF PERIORBITAL HYPERPIGMENTATION

Abstract

Periorbital hyperpigmentation (POH), commonly known as dark circles, is characterized by chromatic alteration of the infraorbital region, presenting brownish, bluish, or violaceous tones. It is a multifactorial condition associated with pigmentary, vascular, and structural factors, with significant aesthetic and psychosocial impact. Given the growing demand for effective therapeutic approaches, collagen biostimulators have been investigated as a complementary alternative in the management of POH, particularly in cases with structural involvement. This study consists of an integrative literature review conducted in the PubMed, SciELO, and CAPES databases, including publications between 2018 and 2025 in Portuguese and English. Original studies, systematic reviews, and academic works with clear methodology and scientific relevance were included. The literature indicates that substances such as poly-L-lactic acid, calcium hydroxyapatite, and polycaprolactone promote neocollagenesis, increased dermal thickness, and improved skin firmness, indirectly contributing to the reduction of darkened appearance caused by skin laxity and shadowing effects. It is concluded that collagen biostimulators may be used as a complementary strategy in the treatment of structural or mixed POH, although further specific and methodologically robust clinical studies focused exclusively on the periorbital region are still required.