EXOSOMES AND PLATELET-RICH PLASMA AS NOVEL REGENERATIVE THERAPIES IN ALOPECIA: A SYSTEMATIC LITERATURE REVIEW

Abstract

Recent studies on regenerative therapies applied to androgenetic alopecia (AGA) demonstrate significant progress in the understanding and effectiveness of approaches such as exosomes, platelet-rich plasma (PRP), and cell therapies. This study is a systematic literature review, designed to analyze recent scientific evidence on regenerative therapies using exosomes, platelet-rich plasma (PRP), and minoxidil in the treatment of androgenetic alopecia. The search was conducted in August 2025 in the PubMed, SciELO, and BVS Regional Portal databases, using the descriptors "alopecia," "exosomes," "stem cells," and "platelet-rich plasma." Sixty-three articles were identified; after applying inclusion and exclusion criteria, eight articles remained for analysis. The results of the analyzed studies reinforce the potential of exosome and PRP therapies as effective and minimally invasive alternatives in the management of androgenetic alopecia. Both treatments demonstrate superior or complementary clinical benefits to those obtained with minoxidil, with a better tolerability profile and more comprehensive biological effects. However, despite the encouraging results, studies converge on the need for standardization of preparation, dosage, and application protocols, as well as larger-scale and long-term clinical trials to confirm the efficacy and safety of these treatments.